Resistance to chemotherapy drugs is a big problem. In some cases resistance is linked with changes in how cells control translation, the step in which proteins are made. Researchers have found drugs that make mouse cancer cells more sensitive to chemotherapy and reduce resistance.
The researchers tested small molecules for their ability to block the start of translation, and found this effect in a group of drugs called cyclopenta[b]benzofurans, which mainly block the start of translation. Members of this group could reverse resistance to cancer drugs in mice with lymphoma. The researchers recommend more research on drugs targeting the protein eIF4A, which could help overcome resistance to cancer drugs.
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